Recommended irradiation dose and time window of local x-ray for spinal cord injury
The glial scar is the main inhibitor of axon regeneration and functional recovery in the central nervous system.
Appropriate dose X-ray irradiation has been shown to inhibit the formation of glial cells, thereby promoting axonal regeneration.
In addition, X-rays militate against the death and degeneration of neurons, and improve the recovery of locomotor function following spinal cord injury. However, the optimal treatment time window and dose of X-irradiation for spinal cord injury is still unknown.
Prof. Shiqing Feng and colleagues from Tianjin Medical University have verified that X-irradiation at a dose of 8 Gy can inhibit glial scar formation at the injury site and alleviate the inflammatory reaction; day 7 post injury may be the optimal time window for topical X-irradiation.
These findings were published in the Neural Regeneration Research (Vol. 8, No. 17, 2013).
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